Author/Authors :
Saeidimehr، Saeid نويسنده Department of Clinical Laboratory, Naft Grand Hospital, Ahvaz, IR Iran , , Ebrahimi، Ammar نويسنده Department of Medical Biotechnology, School of Advanced Medical Technology, Tehran University of Medical Sciences, Tehran, Iran , , Saki، Najmaldin نويسنده Department of Hematology and Blood Banking School of Medical Sciences, Tarbiat Modares University, Tehran, Iran , , Goodarzi، Parisa نويسنده Brain and Spinal Injury Research Center, Tehran University of Medical Sciences , , Rahim، Fakher نويسنده Toxicology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran ,
Abstract :
Ageing is a complex process and a broad spectrum of physical, psychological, and
social changes over time. Accompanying diseases and disabilities, which can interfere
with cancer treatment and recovery, occur in old ages. MicroRNAs (miRNAs) are a
set of small non-coding RNAs, which have considerable roles in post-transcriptional
regulation at gene expression level. In this review, we attempted to summarize the current
knowledge of miRNAs functions in ageing, with mainly focuses on malignancies
and all underlying genetic, molecular and epigenetics mechanisms. The evidences indicated
the complex and dynamic nature of miRNA-based linkage of ageing and cancer
at genomics and epigenomics levels which might be generally crucial for understanding
the mechanisms of age-related cancer and ageing. Recently in the field of cancer and
ageing, scientists claimed that uric acid can be used to regulate reactive oxygen species
(ROS), leading to cancer and ageing prevention; these findings highlight the role of
miRNA-based inhibition of the SLC2A9 antioxidant pathway in cancer, as a novel way to
kill malignant cells, while a patient is fighting with cancer.
