Title of article :
Effect of ischemic preconditioning on the expression of c-myb in the CA1 region of the gerbil hippocampus after ischemia/reperfusion injury
Author/Authors :
-، - نويسنده Department of Internal Medicine, School of Medicine, Kangwon National University, Chuncheon 200-701, South Korea Young Lee, Hui , -، - نويسنده Department of Biomedical Science, Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon 200-702, South Korea Tae, Hyun-Jin , -، - نويسنده Pharmacology & Toxicology Department, Shinpoong Pharmaceutical Co., Ltd., Ansan 425-100, South Korea Cho, Geum-Sil , -، - نويسنده Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon 200-701, South Korea Kim, In Hye , -، - نويسنده Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon 200-701, South Korea Hwi Cho, Jeong , -، - نويسنده Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon 200-701, South Korea Ha Park, Joon , -، - نويسنده Department of Biomedical Science, Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon 200-702, South Korea Hyeon Ahn, Ji , -، - نويسنده Department of Physiology, College of Medicine, Hallym University, Chuncheon 200-702, South Korea Hui Chen, Bai , -، - نويسنده Department of Physiology, College of Medicine, Hallym University, Chuncheon 200-702, South Korea Shin, Bich-Na , -، - نويسنده Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon 200-701, South Korea Won, Moo-Ho , -، - نويسنده Department of Emergency Medicine, School of Medicine, Kangwon National University, Chuncheon 200-701, South Korea Woo Park, Chan , -، - نويسنده Department of Emergency Medicine, School of Medicine, Kangwon National University, Chuncheon 200-701, South Korea Hwi Cho, Jun , -، - نويسنده Department of Emergency Medicine, Chuncheon Sacred Heart Hospital, College of Medicine, Hallym University, Chuncheon 200-702, South Korea Yeol Seo, Jeong , -، - نويسنده Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon 200-701, South Korea Lee, Jae-Chul
Issue Information :
ماهنامه با شماره پیاپی 0 سال 2016
Pages :
8
From page :
624
To page :
631
Abstract :
-
Abstract :
Objective(s): In the present study, we investigated the effect of ischemic preconditioning (IPC) on c-myb immunoreactivity as well as neuronal damage/death after a subsequent lethal transient ischemia in gerbils. Materials and Methods: IPC was subjected to a 2 min sublethal ischemia and a lethal transient ischemia was given 5 min transient ischemia. The animals in all of the groups were given recovery times of 1 day, 2 days and 5 days and we examined change in c-myb immunoreactivity as well as neuronal damage/death in the hippocampus induced by a lethal transient ischemia. Results:A lethal transient ischemia induced a significant loss of cells in the stratum pyramidale (SP) of the hippocampal CA1 region at 5 days post-ischemia, and this insult showed that c-myb immunoreactivity in cells of the SP of the CA1 region was significantly decreased at 2 days post-ischemia and disappeared at 5 days post-ischemia. However, IPC effectively prevented the neuronal loss in the SP and showed that c-myb immunoreactivity was constitutively maintained in the SP after a lethal transient ischemia. Conclusion: Our results show that a lethal transient ischemia significantly decreased c-myb immunoreactivity in the SP of the CA1 region and that IPC well preserved c-myb immunoreactivity in the SP of the CA1 region. We suggest that the maintenance of c-myb might be related with IPC-mediated neuroprotection after a lethal ischemic insult.
Journal title :
Iranian Journal of Basic Medical Sciences
Serial Year :
2016
Journal title :
Iranian Journal of Basic Medical Sciences
Record number :
2390974
Link To Document :
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