T cell immune responses in psoriasis.

A central role for T cells and their cytokines in the pathogenesis of psoriasis has been proposed; however, there are controversies over the details of this issue. The goal of this study is to summarise currently available data on the importance of T cells in psoriasis pathogenesis. A  systematic  review  of  the  English  medical  literature  was  conducted  by  searching PubMed, Embase, ISI Web of Knowledge, and Iranian databases including Iranmedex, and SID for studies on associations between the involvement of T cell subsets and psoriasis. The results of the present study indicate that alterations in the number and function of different subsets of T-cells are associated with psoriasis. It   appears   that   studies   on   T   cell   subsets   contributed   to   understanding   the immunopathogenesis  of  psoriasis.  In  addition,  it  may  have  provided  novel  therapeutic opportunities in ameliorating immunopathologies.