Author/Authors :
Ahmadvand، Hassan نويسنده , , Tavafi، Majid نويسنده Department of Anatomy, Lorestan University of Medical Sciences, Khoramabad, Iran Tavafi, Majid , Asadollahi، Vahideh نويسنده Cellular and Molecular Research Center, Kurdistan University of Medical Sciences, Sanandaj, IR Iran , , Jafaripour، Leila نويسنده Department of Anatomy, Faculty of Medicine, Dezful University of Medical Sciences, Dezful, IR Iran , , Hadipour-Moradi، Forouzan نويسنده Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, IR Iran , , Mohammadrezaei-Khoramabadi، Reza نويسنده Student Research Commititee, Lorestan University of Medical Sciences, Khorramabad, IR Iran , , Khosravi، Peyman نويسنده Student Research Commititee, Lorestan University of Medical Sciences, Khorramabad, IR Iran , , Mahmod Salehi، Hadis نويسنده Department of Clinical Psychology, Shiraz University, Shiraz, IR Iran , , Cheraghi Valujerdi، Ahmad نويسنده Electrical and Computer Engineering Department, Kerman Graduate University of Technology, Kerman, Iran ,
Abstract :
Background
Nephrotoxicity is one of the most important side effects of the use of gentamicin sulphate (GS) resulted in reactive oxygen species generation. Antioxidant compounds played effective roles in reduction of renal injuries caused by using of gentamicin. Carvacrol is a strong antioxidant compound.
Objectives
The aim of this study is to explore the effect of carvacrol inhibition in lesions of gentamicin-induced nephrotoxicity.
Materials and Methods
In this experimental study, 32 male mature Sprague-Dawley rats were divided into 4 groups of 8; group1: control, group 2 sham received daily carvacrol injection (74 mg/kg) for 12 days, group 3 received daily GS injection (100 mg/kg) for 12 days, group 4 received daily GS (100 mg/kg) and carvacrol (74 mg/kg) for 12 days. After 12 days, rats were anaesthetized, blood sample were obtained and kidneys were removed then stained with hematoxylin and eosin method and then were studied histophatologically. Serum creatinine and urea were measured.
Results
Flow treatment of nephrotoxic animals with carvacrol could significantly inhibit leukocyte infiltration (9.42%) and tubular necrosis (38.18%) in comparison with the nephrotoxic untreated group. Carvacrol significantly decreased the levels of urea and creatinine in treated group compared with the nephrotoxic untreated group.
Conclusions
The findings showed that carvacrol alleviates loss of leukocyte infiltration (9.42%) and tubular necrosis and exerts beneficial effects on kidney function test in nephrotoxic group.
