Author/Authors :
Zeraati، Abbasali نويسنده Department of Nephrology, Kidney Transplantation Complications Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IR Iran , , Hami، Maryam نويسنده Department of Nephrology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IR Iran , , Sharifipour، Farzaneh نويسنده Department of Nephrology, Kidney Transplantation Complications Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IR Iran , , Reyahi، Mohammad Reza نويسنده Kidney Transplantation Complications Research Center, Mashhad University of Medical Sciences, Mashhad, IR Iran ,
Abstract :
Background
Few studies have been done on free water excretion capacity in renal transplant recipients.
Objectives
This study was designed to compare electrolyte free water clearance (E-CH2O) in renal transplant recipients with healthy control group.
Methods
A cross-sectional study was conducted to determine three-hour creatinine clearance (CCl), E-CH2O, and percent urine output in 3 hours after administering 20 mL/Kg oral water loading following 12-hour fasting, in 22 renal transplant recipients with good graft function (creatinine < 1.5 mg/dL) and 26 healthy controls. Patients with diabetes mellitus, hypertension, ischemic heart disease, or liver disease, hypovolemia and hypoalbuminemia were excluded. Statistical analysis was done using t-test, K-square, and Pearson’s correlation test.
Results
We recruited 25 recipients (73% patients in living and 27% in cadaveric donor transplantation) and 26 healthy control groups.3 patients refused to collect urine and finally 22 patients finished the protocol. The mean age of subjects was 37.68 ± 13.88 and 31.40 ± 8.20 years old in renal transplant recipients and control groups, respectively. In patient group male to female ratio was 9/13 and in control group was14/12. Although the 3h-CCl was similar (126.49 ± 53.52 vs. 109.99 ± 47.06 mL/min) in two groups (P > 0.05), the E-CH2O (1.83 ± 1.22 vs. 2.94 ± 2.02) and 3-hour urine output percent (55.93 ± 22.86 vs74.11 ± 30.38) in kidney recipients was significantly lower than healthy controls (P < 0.05). There wasn’t any significant correlation between E-CH2O and 3h-CCl in renal transplant recipients. Donor source and gender did not affect 3h-CCl and E-CH2O in renal transplant patients.
Conclusions
This study demonstrated that E-CH2O has been decreased in renal transplant patients in comparison with control group when there was not any difference between3h- CCl in two groups. This indicates that E-CH2O may be decreased earlier than 3h-CCl in transplant patients.
