Author/Authors :
Nakhaeimoghadam، Maryam نويسنده Research Center for Children and Adolescents Health, Zahedan University of Medical Sciences, Zahedan, Iran. Nakhaeimoghadam, Maryam , Setoodeh، Aria نويسنده Growth and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran. AND Department of Pediatric Endocrinology, Childrens Medical Center , Tehran University of Medical Sciences, Tehran, Iran. Setoodeh, Aria , Noori، Noormohammad نويسنده Department of Pediatrics, Children and Adolescent Health Research Center, Zahedan University of Medical Sciences, Zahedan, Iran Noori, Noormohammad , Rostami، Parastoo نويسنده Department of Pediatric Endocrinology, Childrens Medical Center, Tehran University of Medical Sciences, Tehran, Iran. Rostami, Parastoo , Teimouri، Alireza نويسنده Neurosurgery Department, Faculty of Medicine, Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran ,
Abstract :
Background
Survivors of childhood malignancy are at risk of long-term late effects. One of the most commonly involved systems in this effect is endocrine system. Appropriate timely recognition and treatment of late complications including endocrine complication is essential for the continuing health and improvement in quality of life in cancer survivors.
Objectives
Therefore, this study has been conducted to investigate the aforementioned complications resulting from the treatment of the common malignancies in children in Iran.
Patients and Methods
We performed a cross sectional study for evaluation of endocrine complication in cancer survivors who had finished their cancer treatment and come for followed up in oncology clinic of children medical center.
Results
Demographic data, treatment modality, and endocrine late effect recorded and analyzed. There were 96 survivors with median age of 13.8 ± 5.8 years (range 3 - 31 years). The median follow up time was 2.7 years (range 1 - 10 years). Hyperinsulinemia was the most common late effect. Other complication was dyslipidemia, overweight, obesity, osteopenia, hypothyroidism, diabetes mellitus and osteoporosis respectively.
Conclusions
Our study has demonstrated a significant prevalence of endocrine complication after childhood cancer therapy and a long term follow-up program for survivors of childhood cancer is therefore needed.
