Author/Authors :
Jamshidzadeh، Akram نويسنده , , Koohi Hosseinabadi ، Omid نويسنده Stem cell and Transgenic Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. , , Heidari، Reza نويسنده Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. , , Mohammadi Samani، Soliman نويسنده , , Rajabzadeh، Sara نويسنده International Branch, Shiraz University of Medical Sciences, Shiraz, Iran. , , Seyed Raoufi، Seyed Mojtaba نويسنده School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, IR Iran , , Ahmadi Vadeghani، Alireza نويسنده Laparoscopy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. ,
Abstract :
Platelet-rich plasma (PRP) is an attractive preparation in regenerative medicine due to its potential role in the healing process in different experimental models. This study was designed to investigate the wound healing activity of a new formulation of PRP. Different gel-based formulations of PRP were prepared. Open excision wounds were made on the back of male Sprague-Dawley rats, and PRP gel was administered topically once daily until the wounds healed completely (12 days). The results revealed that the tested PRP formulation significantly accelerated the wound healing process by increasing the wound contraction, tissue granulization, vascularization, and collagen regeneration. Interestingly, this study showed that there were no significant differences between the PRP and its gel-based formulation in all the above mentioned parameters. Although this investigation showed that PRP formulation had significant wound healing effects, the PRP gel-based formulation also had significant wound healing properties. This might indicate the wound healing properties of the PRP gel ingredients in the current investigation.
