Title of article :
Predictive Factors of Survival Time after Hematopoietic Stem Cell Transplant in Acute Myeloid Leukemia Patients who Received Allogeneic BMT from Matched Sibling Donors Using Generalized Gamma Models
Author/Authors :
Sayemiri، Kourosh نويسنده Department of Biostatistics, School of Public Health, Tehran University of Medical Sciences, Iran Department of social medicine, School of medicine, Ilam University of Medical Sciences, Iran Sayemiri, Kourosh , Eshraghian، MR نويسنده , , Mohammad، Kazem نويسنده , , Alimoghaddam، Kamran نويسنده Alimoghaddam, K , Rahimi Foroushani، A نويسنده Department of Biostatistics, School of Public Health, Tehran University of Medical Sciences, Iran Rahimi Foroushani, A , Zeraati، H نويسنده Department of Biostatistics, School of Public Health, Tehran University of Medical Sciences, Iran Zeraati, H , Shamshiri، Ahmad Reza نويسنده , , Djafarian، K نويسنده Department of nutrition and biochemistry, School of Public Health, Tehran University of Medical Sciences, Iran Djafarian, K , Ghavamzadeh، Ardeshir نويسنده ,
Issue Information :
دوفصلنامه با شماره پیاپی 0 سال 2009
Pages :
6
From page :
21
To page :
26
Abstract :

Introduction: This paper used Generalized Gamma (GG) distribution to find the predictive factors of overall survival (OS) after haematopoietic stem cell transplant (HSCT) in acute myeloid  leukemia patients.
Methods: Discrimination among the exponential, Weibull, GG, log-logistic, and lognormal distributions was done using maximum likelihood and Akaike information criteria.
Results: The 5-year OS in 301 patients was 65% (95%CI: 60.7-69.3). Peak mortality hazard occurred at months 6-7 after HSCT then, it was U Shape. The data was fitted by GG distribution better than other distributions. Univariate analysis using GG distribution showed a positive association between OS with dose of infused WBC (P=0.018), CD3 (p=0.001), no relapse (P<0.001), cGVHD (P<0.001), and platelet recovery (P<0.001). Multivariate analysis indicated that, OS has relationship with relapse (P<0.001), platelet recovery (P=0.004), disease status at transplant (P=0.036) and aGVHD (P=0.036).
Conclusion: We showed that GG distribution can be a useful tool for recognizing prognostic factors of OS in AML patients.

Journal title :
International Journal of Hematology-Oncology and Stem Cell Research (IJHOSCR)
Serial Year :
2009
Journal title :
International Journal of Hematology-Oncology and Stem Cell Research (IJHOSCR)
Record number :
2393729
Link To Document :
https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=2393729
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