Author/Authors :
Pourostadi، Mahya نويسنده Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, IR Iran , , Rashedi، Jalil نويسنده Tuberculosis and Lung Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. , , Mahdavi Poor ، Behroz نويسنده Department of Laboratory Sciences, Faculty of Paramedicine, Tabriz University of Medical Sciences, Tabriz, Iran , , SAMADI KAFIL، Hossein نويسنده Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran AND Dept. of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran SAMADI KAFIL, Hossein , Agha Kazem Shirazi، Samaneh نويسنده , , Asgharzadeh، Mohammad نويسنده ,
Abstract :
Years after the development of antituberculosis (TB) drugs, many people continue to suffer from this disease. To control the spread of TB, strains of the Mycobacterium tuberculosis complex need to be determined, and sources of infection must be identified. Such steps should help to prevent transmission of the infection. The aim of this study was to perform molecular genotyping of isolates of the M. tuberculosis complex obtained from patients in northwestern Iran. One hundred ninety-four culture-positive M. tuberculosis isolates obtained from patients in northwestern Iran were analyzed using the mycobacterial interspersed repetitive unit-exact tandem repeats (MIRU-ETR) method. The MIRU-ETR method distinguished 162 different patterns in the 194 isolates, comprising 23 clusters and 139 unique patterns. Its discriminatory power according to the Hunter-Gaston discriminatory index (HGDI) was 0.9978. The largest cluster contained six isolates. This research indicated that various strains of M. tuberculosis were responsible for TB and that the majority of cases were due to reactivation.
