Author/Authors :
Zarei Moradi، Shabnam نويسنده Department of Genetics at Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran , , Masoudi، Najmehsadat نويسنده Department of Genetics at Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran , , Mohseni Meybodi، Anahita نويسنده Genetics Department, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran , , Anisi Hemaseh، Khadijeh نويسنده Department of Genetics , Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran , , Mozafari Kermani، Ramin نويسنده , , Shahzadeh Fazeli، Abolhasan نويسنده Child Health and Development Research Center, Iran Medical Science Branch of ACECR, Tehran, Iran , , Gourabi، Hamid نويسنده ,
Abstract :
Background: To verify the hypothesis that the incidence of chromosomal abnormalities
increases in babies conceived by different assisted reproduction procedures. The availability
of the umbilical cord blood encouraged us to study this hypothesis via this method.
Materials and Methods: This is a descriptive study, umbilical cord blood samples of assisted
reproductive technology (ART) children were analyzed with standard cytogenetic
techniques (G banding). Karyotyping was possible in 109 cases.
Results: The number of abnormal cases was four (3.7%), among which, three cases
(2.8%) were inherited and only 1 case (0.9%) was a de novo translocation. In total, the
incidence of de novo chromosomal abnormalities was in the range observed in all live
births in the general population (0.7-1%).
Conclusion: No significant difference in the incidence of chromosomal abnormality was
found between ART and naturally conceived babies. To date, several studies have examined
the medical and developmental outcome of ART children and still have not reached
a definite conclusion. Genetic counseling is recommended as an integral part of planning
of treatment strategies for couples wishing to undergo ART.
