Author/Authors :
Ghasemi Moravej، Fahimeh نويسنده Department of Anatomy, School of Medicine, Hamadan University of Medical Sciences, Hamadan, IR Iran , , Amiri، Iraj نويسنده , , Shahidi، Siamak نويسنده , , Mehdizadeh، Mehdi نويسنده , , Rahimi، Asrin نويسنده Anatomy Department, School of Medicine, Hamadan University of Medical Sciences, Hamadan, IR Iran , , Esmaeilzadeh، Banafsheh نويسنده Faculty of Medicine, Anatomy Department, Bushehr University of Medical Sciences, Bushehr, IR Iran , , Soleimani Asl، Sara نويسنده Department of Anatomical Sciences, Hamadan University of Medical Sciences, Hamadan, Iran ,
Abstract :
The administration of 3-4-methylenedioxymethamphetamine (MDMA) leads to learning and memory impairment. Due to the effect of neurogenesis on memory and learning, in this study, we investigated the effects of MDMA on NeuN expression (a marker of neurogenesis) in the hippocampus. Adult male Wistar rats (weighing 200 - 250 g) received a single intraperitoneal dose of 10 mg/kg of MDMA or were left undisrupted. The expression of NeuN was assessed using the immunohistochemistry method 7, 14, 28, and 60 days following MDMA administration. Our results showed that MDMA administration caused a decrease in NeuN expression in the experimental group compared with the control group. These results suggest a negative correlation between MDMA administration and adult hippocampal neurogenesis.
