Title of article
A Patient With Primary Biliary Cirrhosis Accompanied by Wilson’s Disease
Author/Authors
Zhao، Su Xian نويسنده Department of Traditional and Western Medical Hepatology, Third Hospital of Hebei Medical University, Shijiazhuang, China Zhao, Su Xian , Zhang، Yu Guo نويسنده Department of Traditional and Western Medical Hepatology, Third Hospital of Hebei Medical University, Shijiazhuang, China Zhang, Yu Guo , Wang، Rong Qi نويسنده Department of Traditional and Western Medical Hepatology, Third Hospital of Hebei Medical University, Shijiazhuang, China Wang, Rong Qi , Li، Wen-Cong نويسنده Department of Traditional and Western Medical Hepatology, Third Hospital of Hebei Medical University, Shijiazhuang, China , , Kong، Ling Bo نويسنده Department of Traditional and Western Medical Hepatology, Third Hospital of Hebei Medical University, Shijiazhuang, China Kong, Ling Bo , Kong، Li نويسنده Department of Traditional and Western Medical Hepatology, Third Hospital of Hebei Medical University, Shijiazhuang, China Kong, Li , Nan، Yue Min نويسنده Department of Traditional and Western Medical Hepatology, Third Hospital of Hebei Medical University, Shijiazhuang, China Nan, Yue Min
Issue Information
ماهنامه با شماره پیاپی 0 سال 2016
Pages
4
From page
1
To page
4
Abstract
Both primary biliary cirrhosis (PBC) and Wilson’s disease (WD) can cause copper retention in the liver, which is an important factor for liver cellular damage. Copper chelation may preserve liver cell function. It is challenging to distinguish WD from copper accumulation in patients with PBC. There have been few case reports of PBC co-occurrence with WD. Here we report a case of PBC with WD in a 55-year-old Chinese male. In addition to the typical pathological characteristics of PBC and a large number of copper depositions in the liver, the patient showed WD ATP7B gene mutations. Co-occurrence of PBC with WD is rare, which can cause diffusely intrahepatic copper deposition. Early liver biopsy and genetic testing are necessary for the diagnosis. The combination of ursodeoxycholic acid with zinc and sodium dimercaptopropane sulfonate is effective.
Journal title
Hepatitis Monthly
Serial Year
2016
Journal title
Hepatitis Monthly
Record number
2394717
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