Author/Authors :
Hassas Yeganeh، Mehrnoush نويسنده Department of Paediatric Rheumatology, Mofid Children’s Hospital, Shahid Behshti University of Medical Sciences, Tehran, IR Iran , , Zafari، Neda نويسنده Medical Student, Mofid’s Children Hospital, Shahid Behshti University of Medical Sciences, Tehran, IR Iran , , Sardarinia، Mahsa نويسنده Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran , , Mahboubi، Leyla نويسنده Department of Paediatric Rheumatology, Mofid Children’s Hospital, Shahid Behshti University of Medical Sciences, Tehran, IR Iran , , JAVADI PARVANEH، Vadood نويسنده 2. Fellow of Pediatric Rheumatology, Shahid Beheshti University of Medical Sciences, Mofid Children’s Hospital, Tehran-Iran , , Salehi Abari، Shima نويسنده Department of Pediatrics, Faculty of Medicine, and Child Health Promotion Research Center, IUMS, Isfahan , , Sinaii، Reza نويسنده Department of Paediatric Rheumatology, Mofid Children’s Hospital, Shahid Behshti University of Medical Sciences, Tehran, IR Iran , , Freshteh Mehregan، Fatemeh نويسنده Department of Paediatric Rheumatology, Mofid Children’s Hospital, Shahid Behshti University of Medical Sciences, Tehran, IR Iran , , Rahmani، Khosro نويسنده Department of Paediatric Rheumatology, Mofid Children’s Hospital, Shahid Behshti University of Medical Sciences, Tehran, IR Iran , , SHIARI، Reza نويسنده MD,Ph.D,Assistant Professor of Pediatric Rheumatology,Shahid Beheshti University of Medical Sciences,Tehran,Iran ,
Abstract :
An 11-year-old female patient with autoimmune hepatitis (AIH) was referred to our rheumatology clinic due to her current musculoskeletal manifestations. The patient had been diagnosed with AIH 3 months previously, based on jaundice and impaired liver function tests, and she had been treated with low-dose prednisolone and azathioprine. She presented with malaise, arthritis, a malar rash on the face, and oral ulcers. Laboratory tests revealed a positive ANA/anti-dsDNA test. Liver biopsy showed chronic hepatitis with severe inflammatory activity, in favor of a diagnosis of definite AIH. She fulfilled the international criteria for both SLE and AIH. The clinical symptoms and laboratory findings of SLE improved with ongoing treatment with corticosteroids and azathioprine, accompanied with hydroxychloroquine sulfate. The present case indicates that AIH can be the first manifestation of SLE in children.
