Author/Authors :
JAVADI PARVANEH، Vadood نويسنده 2. Fellow of Pediatric Rheumatology, Shahid Beheshti University of Medical Sciences, Mofid Children’s Hospital, Tehran-Iran , , SHIARI، Reza نويسنده MD,Ph.D,Assistant Professor of Pediatric Rheumatology,Shahid Beheshti University of Medical Sciences,Tehran,Iran ,
Abstract :
Familial Mediterranean Fever (FMF) is an auto-inflammatory disease presenting with periodic fever and various clinical manifestations. Almost 10% of the patients with FMF do not respond to colchicine therapy. Herein was reported a colchicine non-responsive patient with accurate diagnosis and early treatment of FMF. She had presented with recurrent and persistent acute abdominal pain attacks and several abdominal surgeries. Addition of recombinant interleukin-1 receptor antagonist (Anakinra) to colchicine was effective to decrease the number and severity of abdominal pain in the patient. This case showed the effect of additional Anakinra on children with FMF who were colchicine resistant.
