Author/Authors :
Shamsizadeh، Ali نويسنده , , Fatehi، Farangis نويسنده Department of physiology, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran , , Khajehasani، Fatemeh نويسنده Department of Radiology, Rasoul-e-Akram Hospital, Iran University of Medical Sciences, Tehran, IR Iran , , HASSANSHAHI، GHOLAMHOSSEIN نويسنده , , Kazemi Arababadi، Mohammad نويسنده ,
Abstract :
The exact pathogenesis of epilepsy is not clear well. Recent studies showed the possible involvement of transient receptor potential vanilloid type 1 (TRPV1) receptors in this disease. The aim of this study was to measure the expression of TRPV1 receptors in hippocampus following pentylenetetrazole (PTZ)-induced kindling in male rats. In this experimental study, 14 male Wistar rats were allocated into two groups of experimental and control (seven rats in each group). The kindling group received a subconvulsive dose of PTZ (35 mg/kg, intraperitoneally) every 48 hours for 15 sessions, while the control rats were injected with an equal dose of saline. At the end of the injections, rats were decapitated, and their brains were removed. TRPV1 receptor expression in hippocampus region was assessed by real-time polymerase chain reaction method. The results of the current study showed that expressions of TRPV1 receptors were increased in hippocampus following PTZ-induced kindling in male rats. Since the expression of TRPV1 receptors increased in hippocampus of epileptic rats, the TRPV1 receptors may be good candidates for epilepsy treatment.
