Author/Authors :
Bakhshandeh، Hooman نويسنده , , Alavi، Mostafa نويسنده , , Ghadrdoost، Behshid نويسنده Laboratory of Learning and Memory, Research Center and Department of Physiology, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran. , , Farsad، Fariborz نويسنده Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IR Iran , , Zavarei، Abbas نويسنده Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IR Iran , , Ziaeifard، Mohsen نويسنده Assistant Professor, Department of Anesthesiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran , , Farasatkish، Rasoul نويسنده , , Babaei، Tooraj نويسنده Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IR Iran , , Baharestani، Bahador نويسنده Shaheed Rajaiee Cardiovascular Research Center, Tehran, Iran. , , Golpira، Reza نويسنده Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IR Iran ,
Abstract :
Coagulopathy after cardiopulmonary bypass (CPB) may lead to increased morbidity and mortality. Routine conventional coagulation tests are not always suitable to detect rapid changes in patient’s coagulation status. A point-of-care instrument such as ROTEM (rotational thromboelastometry) is a timely and comprehensive method to evaluate hemostasis during cardiac surgery may reduce the need for blood transfusion. In this study, ROTEM was compared to coagulation tests routinely performed during cardiac surgery for postoperative bleeding volume and consumption of blood products. Fifty patients undergoing cardiac surgical procedures were enrolled. Blood was obtained before the operation and after CPB weaning. Twenty-five of patients were checked only by traditional blood coagulation test and 25 other patients were checked by ROTEM in addition to routine coagulation tests. The results of these two groups of patients were compared. There was a significant correlation between platelet count (PLT) and fibrinogen level with EXTEM-MCF (r = 0.79, P value: 0.008, r = 0.55, P value: 0.04 respectively). EXTEM-CT was correlated with prothrombin time (PT) (r = 0.56, P value: 0.01) and International normalized Ratio (INR) (r = 0.57, P value: 0.01). There was a significant correlation between PLT count and fibrinogen level with INTEM-MCF (r = 0.69, P value: 0.02, r = 0.71, P value: 0.01, respectively). INTEM-CT was correlated with partial thromboplastin time (PTT) (r = 0.57, P value: 0.02). There was a significant correlation between FIBTEM-MCF and fibrinogen level (r = 0.80, P value: 0.001). HEPTEM was not correlated with any of the coagulation variables. Postoperative consumption of packed blood cell (BPC) was increased in non-ROTEM group in comparison with ROTEM group (645.17 ± 279.16 in Non-ROTEM vs. 387.50 ± 262.88 in ROTEM, P: 0.03) ROTEM can be used to detect postoperative hemostatic changes following cardiac surgery appropriately and can be useful to choose suitable blood products that may reduce the need for blood transfusion, contributing to better patient blood management.
