Author/Authors :
Riani، Etty نويسنده Department of Aquatic Resources Management, Faculty of Fishery and Marine Science, Bogor Agricultural University. Jl. Lingkar Akademik, Kampus IPB Darmaga, Bogor, West Java, Indonesia Riani, Etty , Chairunissa، Chairunissa نويسنده Faculty of Veterinary Medicine, Bogor Agricultural University, Jl. Agatis, Kampus IPB Darmaga, Bogor, West Java, Indonesia , Chairunissa , Maheswari، Hera نويسنده Faculty of Veterinary Medicine, Bogor Agricultural University, Jl. Agatis, Kampus IPB Darmaga, Bogor, West Java, Indonesia Maheswari, Hera , Dzikrifishofa، Muhammad نويسنده Regional General Hospital of Leuwiliang, Regency of Bogor, Cibeber I, Leuwiliang, Bogor, West Java, Indonesia Dzikrifishofa, Muhammad , Kusumorini، Nastiti نويسنده Faculty of Veterinary Medicine, Bogor Agricultural University, Jl. Agatis, Kampus IPB Darmaga, Bogor, West Java, Indonesia Kusumorini, Nastiti
Abstract :
Introduction: Sandfish (Holothuria scabra) is a marine species generally sold as a raw material that has been dried even though the meat contains steroid hormone with high economic value, which has the potential to become a source of safe natural steroid hormone. This study was aimed to look at the potency of sandfish as an anti-aging for menopausal women. Sandfish could become a source of natural steroid for hormone replacement therapy to replace synthetic hormone that is proven to have negative impacts on health.
Methods: This study used female rats (Rattus norvegicus) Sprague-Dawley Strain Variety II that were twelve weeks old and ovariectomized. In these animals, the bioassay test was conducted with the treatment of sandfish meat powder (SP) containing 30, 40, and 50 µg steroid/100 g. At the end of the treatment, the examination was carried out toward the concentration of steroid in blood serum using radioimmunoassay (RIA) and the uterine weight.
Results: The treatment with SP in 30 µg steroid/100 g could increase the estradiol hormone in blood serum of test animals that were ovariectomized and produce the highest concentration of uterine weight.
Conclusion: This study showed that a dose of SPcontaining 30 µg steroid/100 g body weight had the highest potential as an anti-aging in menopausal women.
