Title of article
The Roles of T Helper 1, T Helper 17 and Regulatory T Cells in the Pathogenesis of Sarcoidosis
Author/Authors
Mortaz، Esmaeil نويسنده Assistant to Editor-in-Chief , , Rezayat، Fatemeh نويسنده Department of Psychiatric Nursing, Tehran University of Medical Sciences, Tehran, Iran; , , Amani ، Davar نويسنده Department of Immunology, School of Medicine , , Kiani، Arda نويسنده Tracheal Disease Research Center,NRITLD, Shahid Beheshti University M.C., TEHRAN-IRAN. , , Garssen، Johan نويسنده Division of Pharmacology and Pathophysiology Utrecht Institute for Pharmaceutical Sciences, Faculty of Sciences, Utrecht University, Utrecht, The Netherlands. Garssen, Johan , Adcock، Ian M. نويسنده Airways Disease Section, National Heart and Lung Institute, Imperial College London, London, UK Adcock, Ian M. , Velayati، Aliakbar نويسنده Clinical Tuberculosis and Epidemiology Research Center, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran ,
Issue Information
دوماهنامه با شماره پیاپی 0 سال 2016
Pages
6
From page
334
To page
339
Abstract
Sarcoidosis is a systemic granulomatous disorder of unidentified etiology, with a heterogeneous clinical presentation. It is characterized by a reduced delayed-type hypersensitivity to tuberculin and common antigens. The balance between Th1, Th17 and Regulatory T(Treg) cells controls T-cell proliferation and activation.The Th17/Treg ratio in the peripheral blood and bronchoalveolar lavage fluidis increased in patients with active sarcoidosis. Amplified IL-17A expression in granulomas and the presence of IL-17A+, IL-17A+IL-4+ and IL-17A+IFN-γ+ memory T helper cells in the circulation and BAL indicate Th17 cell involvement in granuloma induction and/or maintenance in sarcoidosis. Sarcoidosis should therefore be considered as a Th1/Th17 multisystem disorder and anti-IL-17/Th17 approaches that control and reduce IL-17Amay be an option, therefore, for the treatment of sarcoidosis.Here we provide a short overview as to the role of Th17 cells as critical cells in the pathogenesis of sarcoidosis.
Journal title
Iranian Journal of Allergy, Asthma and Immunology
Serial Year
2016
Journal title
Iranian Journal of Allergy, Asthma and Immunology
Record number
2395632
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