Electrochemical Study of Some Charge-Transfer Complexes Involving Amitriptyline and Nortriptyline and Determination of Drugs

: ازمطالعات اسپكتروفتومتري و الكتروشيمي براي تجزيه كمي آمي تريپتيلين هيدروكلريد (ATH) و نورتريپتيلين (NTH) هيدروكلريد استفاده شده است. تيتراسيون هدايت سنجي در محلول آبي با استفاده از يد، دوپامين و سرتونين به عنوان تيترانت انجام شده است. مكانيزم روش اسپكتروفتومتري آن است كه مولكول دارو ابتدا بوسيله مخلوط برومات/ بروميد اكسيده و برومينه مي شود و سپس باقيمانده برومات معرف رنگي را بي رنگ مي سازد. پس غلظت دارو متناسب با جذب معرف مي باشد.

Spectrophotometric and electrochemical studies were successfully used in quantitative analysis of Amitriptyline Hydrochloride (ATH) and Nortriptyline Hydrochloride (NTH). Conductometric titration were carried out in equeous solution using iodide and dopamine and serotonine as titrant. Two new methods using spectrophotometry are dascribed for the determination of (ATH) and (NTH) with potassium bromate as the oxidizing agent and acid dyes, Methyl orange and Indigo carmine. Both spectrophotometric methods are based on the oxidation of mentioned drugs by a known excess of bromate in acid medium and in the presence of excess of bromide followed by estimation of surplus oxidant by reacting with either Indigo carmine (method A) or Methyl orange (method B) and measuring the absorbance at 609 or 507 nm.