Author/Authors :
Showraki ، Najmeh نويسنده Post Graduate Student, Dept. of Oral Medicine, School of Dentistry, Shiraz University of Medical sciences, Shiraz, Iran. , , Mardani ، Maryam نويسنده Dept. of Oral Medicine, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran. , , Emamghoreishi، Masoumeh نويسنده Department of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran , , Andishe-Tadbir، Azadeh نويسنده Dept. of Oral and Maxillofacial Pathology, Prevention and Treatment of Oral and Dental Diseases Research Center, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran. , , Aram، Alireza نويسنده Transgenic Technologies Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. , , Mehriar، Peiman نويسنده School of Dentistry, University of Southern California, Los Angeles, USA. , , Omidi، Mahmoud نويسنده Department of Toxicology, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran. , , Sepehrimanesh، Masood نويسنده Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran , , Koohi Hosseinabadi ، Omid نويسنده Stem cell and Transgenic Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. , , Tanideh، Nader نويسنده ,
Abstract :
Statement of the Problem: Oral mucositis (OM) is a common side effect of anti-cancer drugs and needs significant attention for its prevention.
Purpose: This study aimed to evaluate the healing effects of olive leaf extract on 5-fluorouracil-induced OM in golden hamster.
Materials and Method: OM was induced in 63 male golden hamsters by the combination of 5-fluorouracil injections (days 0, 5 and 10) and the abrasion of the cheek pouch (days 3 and 4). On day 12, hamsters were received topical olive leaf extract ointment, base of ointment, or no treatment (control) for 5 days. Histopathology evaluations, blood examinations, and tissue malondialdehyde level measurement were performed 1, 3 and 5 days after treatments.
Results: Histopathology score and tissue malondialdehyde level were significantly lower in olive leaf extract treated group in comparison with control and base groups (p= 0.000). Significant decreases in white blood cell, hemoglobin, hematocrit , and mean corpuscular volume and an increase in mean corpuscular hemoglobin concentration were observed in olive leaf extract treated group in comparison with control and base groups (p < 0.05).
Conclusion: Our findings demonstrated that daily application of olive leaf extract ointment had healing effect on 5-fluorouracil induced OM in hamsters. Moreover, the beneficial effect of olive leaf extract on OM might be due to its antioxidant and anti-inflammatory properties.
Keywords ? 5- fluorouracil ? Anti-inflammatory ? Antioxidant ? Olive Leaf ? Oral Mucositis
