Author/Authors :
Alavi، M نويسنده Ionizing and Non-Ionizing Radiation Protection Research Center, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran , , Taeb، S نويسنده Ionizing and Non-Ionizing Radiation Protection Research Center, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran , , Okhovat، M A نويسنده Diagnostic Laboratory Sciences and Technology Research Center, School of Paramedical Sciences, Shiraz University of Medical sciences, Shiraz, Iran , , Atef، M نويسنده Ionizing and Non-Ionizing Radiation Protection Research Center, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran , , Negahdari، F نويسنده Department Of Mathematics, Neyriz Branch, Islamic Azad University, Neyriz, Iran ,
Abstract :
Background: Hormesis is defned as the bio-positive response of something which
is bio-negative in high doses. In the present study, the effect of radiation hormesis was
evaluated on the survival rate of immunosuppressed BALB/c mice by Cyclosporine A.
Material and Methods: We used 75 consanguine, male, BALB/c mice in
this experiment. The frst group received Technetium-99m and the second group was
placed on a sample radioactive soil of Ramsar region (800Bq) for 20 days. The third
group was exposed to X-rays and the fourth group was placed on the radioactive soil
and then injected Technetium-99m. The last group was the sham irradiated control
group. Finally, 30mg Cyclosporine A as the immunosuppressive agent was orally administered to all mice 48 hours after receiving X-rays and Technetium-99m. The mean
survival rate of mice in each group was estimated during time.
Results: A log rank test was run to determine if there were differences in the survival distribution for different groups and related treatments. According to the results,
the survival rate of all pre-irradiated groups was more than the sham irradiated control
group (p < .05). The highest survival time was related to the mice which were placed
on the radioactive soil of Ramsar region for 20 days and then injected Technetium-
99m.
Conclusion: This study confrmed the presence of hormetic models and the enhancement of survival rate in immunosuppressed BALB/c mice as a consequence of
low-dose irradiation. It is also revealed the positive synergetic radioadaptive response
on survival rate of immunosuppressed animals.
