Author/Authors :
Eizadi، Mojtaba نويسنده Department of Physical Education and Sport Sciences,
Islamshahr Branch, Islamic Azad Uniersity, Tehran, IR
Iran , , Ravasi، Ali Asghar نويسنده Faculty of Sport Science, Tehran University, Tehran, IR Iran , , Soory، Rahman نويسنده Department of Exercise Physiology, College of Physical
Education and Sport Sciences, University of Tehran, Tehran, IR
Iran , , Baesi، Kazem نويسنده Department of Virology, Faculty of Medical Sciences, Tarbiat Modares University, P.O. Box 14115-331, Tehran, I.R. Iran , , Choobineh، Sirous نويسنده Department of Exercise Physiology, College of Physical
Education and Sport Sciences, University of Tehran, Tehran, IR
Iran ,
Abstract :
Resistance exercise is recommended as a useful therapeutic tool for
the treatment of type 2 diabetes (T2D); however, the frequency of
studies is inadequate to establish the precise mechanisms of any
association between them. In this study, we aimed to assess the effect
of three months of resistance training on TCF7L2 expression in
pancreatic tissues, serum insulin and glucose. For this purpose, type 2
diabetes (T2D) was induced by intraperitoneal
streptozotocin-nicotinamide in eighteen male Wistar rats aged 10 weeks
(220 ± 30 g). Then, the rats were randomly divided into exercise and
control groups. The exercise rats completed a three-month resistance
training intervention that included climbing on a stepladder for 5 days
weekly. The control group did not participate in exercise intervention.
Fasting glucose and insulin were measured before and after injection (7
days) and after intervention. TCF7L2 gene expression of pancreatic
tissues was measured in both groups after the exercise treatment, and
the ratio between the two groups was calculated. Fasting glucose
increased and serum insulin decreased significantly by T2D induction in
the two groups at baseline. Resistance training resulted in a decrease
in fasting glucose and an increase in insulin in exercise rats. Data
also showed that TCF7L2 gene expression decreased after resistance
training compared with the control group. Based on these data, increased
serum insulin can be attributed to a decrease in TCF7L2 gene expression
of pancreatic cells by resistance training in T2D rats.
