Author/Authors :
Araghi، Atefeh نويسنده Faculty of Veterinary Medicine,Amol University of Special Modern Technologies,Amol,Iran , , Seifi، Saeed نويسنده Faculty of Veterinary Medicine,Amol University of Special Modern Technologies,Amol,Iran , , Sayrafi، Reza نويسنده Faculty of Veterinary Medicine,Amol University of Special Modern Technologies,Amol,Iran , , Sadighara، Parisa نويسنده Faculty of Public Health,Department of Environmental Health Engineer, Food Safety Division,Tehran University of Medical Sciences,Tehran,Iran, Islamic Republic of ,
Abstract :
Objective: Rice Bran Oil (RBO) is extracted from the outer layer of rice. Little information is available regarding its safety. The present study was conducted to assess its safety in chicken embryo model. Materials and Methods: RBO was injected on day 4 of incubation of chickens. The tissues and serum sles were collected. Oxidative stress parameters in the liver, kidney and brain and biochemical parameters of serum were measured. The deformities were also investigated. Results: The changes in the liver enzymes activity were not statistically significant. There was significant decrease and increase in lipid peroxidation and glutathione level, respectively. It is suggested that RBO is a natural antioxidant source. Lowdensity lipoprotein cholesterol (LDL) also decreased. No abnormal findings were observed in the chickens. Conclusion: No toxic effect was observed following RBO administration in chicken embryos. This study showed that RBO is not a safety concern.
Keywords :
Safety assessment , Rice bran oil , Malformations , oxidative stress
