Author/Authors :
Najafian، Bita نويسنده Department of Pediatrics, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran , , Shahverdi، Ehsan نويسنده Students’ Research Committee, Baqiyatallah University of
Medical Sciences, Tehran, IR Iran , , Afsharpaiman، Shahla نويسنده Department of Pediatrics, Health Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. Afsharpaiman, Shahla , Shohrati، Majid نويسنده Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran , , Karimi، Shahram نويسنده Faculty of Engineering, Higher Education and Research West Complex, Kermanshah, Iran , , Konjedi، Mohammad Amin نويسنده Students’ Research Committee, Baqiyatallah University of
Medical Sciences, Tehran, IR Iran ,
Abstract :
The national program of neonatal screening was performed in 2005 in
Iran. According to the studies, the outbreak of congenital
hypothyroidism (CH) was one in every 670 live births in 2011. The
prevalence of the disease in the world is 1 in 3000. The mean prevalence
of this disease in Iran is estimated to be 1 in 1,000, which indicates a
high prevalence of the disease in Iran. This study was conducted to
investigate the prevalence of congenital hypothyroidism among neonates
in the Najmiyeh hospital in Tehran, Iran. This cross-sectional study was
conducted from 2011 to 2014. Most heel blood samples were taken between
three and seven days of birth. Thyroid stimulating hormone (TSH) was
tested using the enzyme-linked immunosorbent assay method. Neonates with
abnormal screening results (TSH > 10 mIU/L, Free T4 < 1.6
mg/dL) were re-examined. Data were analyzed using the SPSS software. A
total of 11427 infants were screened. Of 399 re-called subjects (re-call
rate = 3%), 57 cases were detected with CH, a CH prevalence of 1:200
(the female:male ratio of 1:1.5). The prevalence of CH in our center is
high. These results emphasize the importance of the congenital screening
program.
