Author/Authors :
Balan، Preethi نويسنده Faculty of Dentistry, Sree Anjaneya Institute of Dental Sciences,Department of Oral Medicine and Radiology,Kerala University of Health Sciences (KUHS),Calicut,India , , Gogineni، Subhas B نويسنده Faculty of Dentistry, AB Shetty Memorial Institute of Dental Sciences,Department of Oral Medicine and Radiology,Nitte University,Mangalore,India , , Sucheta، Kumari N نويسنده K.S. Hegde Medical Academy,Department of Biochemistry,Nitte University,Mangalore,India , , Shetty، Veena نويسنده K.S. Hegde Medical Academy,Department of Microbiology,Nitte University,Mangalore,India , , Rangare، Anusha Lakshman نويسنده Century International Institute of dental Sciences & Research Center,Department of Oral medicine and Radiology,Kerala University of Health Sciences (KUHS),Kasargode,India , , Castelino، Renita L نويسنده AB Shetty Memorial Institute of Dental Sciences,Department of Oral medicine and Radiology,Nitte University,Mangalore,India , , Fazil، Areekat K نويسنده Sree Anjaneya Institute of Dental Sciences,Department of Oral medicine and Radiology,Kerala University of Health Sciences (KUHS),Calicut,India ,
Abstract :
Background and aims. The aim of this study was to establish a
relationship between salivary glucose levels and Candida carriage rate
in type 2 diabetes mellitus patients and assess the growth
characteristics and acid production of Candida in glucosesupplemented
saliva.Materials and methods. A total of 90 subjects, 30 with controlled
type 2 diabetes, 30 with uncontrolled type 2 diabetes and 30 without
diabetes (control subjects), aged 3060 years, participated in the
study. Unstimulated saliva was collected and investigated for glucose
levels (GODPOD method), colonyforming units (CFU) of Candida and
salivary pH, using Indikrom paper strips). Analysis of statistical
significance of salivary glucose and PH levels was carried out using
post hoc Tukey HSD test. Correlation of Candida carriage rate with
salivary glucose and salivary PH in the study groups and control group
was made using Pearson’s correlation.Results. Candida CFUs were
significantly higher in diabetic subjects, with a significant and
positive correlation with salivary glucose levels. There was a negative
correlation between salivary PH levels and Candida carriage
rate.Conclusion. Increased salivary glucose was associated with
increased prevalence of oral Candida in diabetic subjects. The growth of
Candida in saliva was accompanied by a rapid decline in PH, which in
turn favored their growth.
