Author/Authors :
?ltemir Duvan، Z.Candan نويسنده Department of Obstetrics and Gynaecology, School of Medicine, Turgut Ozal University, Ankara, Turkey , , Kalem، Müberra Namli نويسنده Department of Obstetrics and Gynaecology, School of Medicine, Turgut Ozal University, Ankara, Turkey , , Onaran، Yuksel نويسنده Department of Obstetrics and Gynaecology, School of Medicine, Turgut Ozal University, Ankara, Turkey , , Keskin، Esra Aktepe نويسنده Department of Obstetrics and Gynaecology, School of Medicine, Turgut Ozal University, Ankara, Turkey , , Ayrim، Aylin نويسنده Department of Obstetrics and Gynaecology, School of Medicine, Turgut Ozal University, Ankara, Turkey , , Pekel، Aslihan نويسنده Department of IVF-Embriology, School of Medicine, Turgut Ozal University, Ankara, Turkey , , Kafali، Hasan نويسنده Department of Obstetrics and Gynaecology, School of Medicine, Turgut Ozal University, Ankara, Turkey , , Turhan، Nilgun نويسنده Department of Obstetrics and Gynaecology, School of Medicine, Mu?la S?tk? Koçman University, Mu?la, Turkey ,
Abstract :
Background: Coasting can reduce the ovarian hyperstimulation syndrome (OHSS) risk
in ovulation induction cycles before intracytoplasmic sperm injection (ICSI). This study
aimed to investigate the effect of gonadotropin-releasing hormone (GnRH) agonist and
GnRH antagonist protocols to controlled ovarian hyperstimulation (COH) cycles with
coasting on the parameters of ICSI cycles and the outcome.
Materials and Methods: In a retrospective cohort study, 117 ICSI cycles were performed
and coasting was applied due to hyperresponse, between 2006 and 2011. The
ICSI outcomes after coasting were then compared between the GnRH agonist group
(n=91) and the GnRH antagonist group (n=26).
Results: The duration of induction and the total consumption of gonadotropins were
found to be similar. Estradiol (E2) levels on human chorionic gonadotropin (hCG) day
were found higher in the agonist group. Coasting days were similar when the two groups
were compared. The number of mature oocytes and the fertilization rates were similar in
both groups; however, the number of grade 1 (G1) embryos and the number of transferred
embryos were higher in the agonist group. Implantation rates were significantly higher
in the antagonist group compared to the agonist group. Pregnancy rates/embryo transfer
rates were higher in the antagonist group; however, this difference was not statistically
significant (32.8% for agonist group vs. 39.1% for antagonist group, P > 0.05).
Conclusion: The present study showed that applying GnRH-agonist and GnRH-antagonist
protocols to coasted cycles did not result in any differences in cycle parameters and
clinical pregnancy rates.
Keywords: Ovarian Hypers
