Author/Authors :
Hoyos، Luis R. نويسنده Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit Medical Center, Detroit, MI, USA , , Khan، Sana N نويسنده Department of Obstetrics and Gynecology, Section of Reproductive Endocrinology and Infertility, Wayne State University School of Medicine, Detroit, USA , , Dai، Jing نويسنده C.S. Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit Medical Center, Detroit, MI, USA , , Singh، Manvinder نويسنده Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit Medical Center, Detroit, MI, USA , , Diamond، Michael P. نويسنده , , Puscheck، Elizabeth E. نويسنده Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit Medical Center, Detroit, MI, USA , , Awonuga، Awoniyi O. نويسنده Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit Medical Center, Detroit, MI, USA ,
Abstract :
Background: Currently, there is no agreement on the optimal urinary derived human
chorionic gonadotropin (u-hCG) dose requirement for initiating final oocyte maturation
prior to oocyte collection in in vitro fertilization (IVF), but doses that range from 2500-
15000 IU have been used. We intended to determine whether low dose u-hCG was effective
for oocyte maturation in IVF/intracytoplasmic sperm injection (ICSI) cycles independent
of body mass index (BMI).
Materials and Methods: We retrospectively evaluated a cohort of 295 women who
underwent their first IVF/ICSI cycles between January 2003 and December 2010 at
the Division of Reproductive Endocrinology and Infertility, Wayne State University,
Detroit, MI, USA. Treatment cycles were divided into 3 groups based on BMI (kg/
m2): < 25 (n=136), 25- < 30 (n=84), and ?30 (n=75) women. Patients received 5000,
10000 or 15000 IU u-hCG for final maturation prior to oocyte collection. The primary
outcome was clinical pregnancy rates (CPRs) and secondary outcome was live birth
rates (LBRs).
Results: Only maternal age negatively impacted (P < 0.001) CPR [odds ratio (OR=0.85,
confidence interval (CI: 0.79-0.91)] and LBR (OR=0.84, CI: 0.78-0.90).
Conclusion: Administration of lower dose u-hCG was effective for oocyte maturation in
IVF and did not affect the CPRs and LBRs irrespective of BMI. Women’s BMI need not
be taken into consideration in choosing the appropriate dose of u-hCG for final oocyte
maturation prior to oocyte collection in IVF. Only maternal age at the time of IVF negatively
influenced CPRs and LBRs in this study.
