Author/Authors :
Romito، Ilaria نويسنده Department of General Surgery and Medical Surgical Specialties, University of Catania, Catania, Italy , , Gulino، Ferdinando Antonio نويسنده Department of General Surgery and Medical Surgical Specialties, University of Catania, Catania, Italy , , Laganà، Antonio Simone نويسنده Unit of Gynecology and Obstetrics, Department of Human Pathology in Adulthood and Childhood, G. Barresi, University of Messina, Messina, Italy , , Giovanni Vitale، Salvatore نويسنده Unit of Gynecology and Obstetrics, Department of Human Pathology in Adulthood and Childhood “G. Barresi”, University of Messina, Messina, Italy , , Tuscano، Attilio نويسنده Department of General Surgery and Medical Surgical Specialties, University of Catania, Catania, Italy , , Leanza، Gianluca نويسنده Department of General Surgery and Medical Surgical Specialties, University of Catania, Catania, Italy , , Musmeci، Giulia نويسنده Department of Experimental and Clinical Pharmacology, University of Catania, Catania, Italy , , Leanza، Vito نويسنده Department of General Surgery and Medical Surgical Specialties, University of Catania, Catania, Italy , , Rapisarda، Agnese Maria Chiara نويسنده Department of General Surgery and Medical Surgical Specialties, University of Catania, Catania, Italy , , Palumbo، Marco Antonio نويسنده Department of General Surgery and Medical Surgical Specialties, University of Catania, Catania, Italy ,
Abstract :
Background: One the main aspects of in vitro fertilization (IVF) cycle is to avoid any
possible systemic damage on women undergoing a controlled ovarian hyperstimulation
(COH). The aim of this work is to evaluate renal and hepatic function blood tests in patients
undergoing controlled ovarian hyperstimulation during IVF cycles.
Materials and Methods: We performed a prospective cohort analysis. All patients received
a long stimulation protocol with gonadotropin-releasing hormone (GnRH) analogues
by daily administration, since the twenty-first day of the previous ovarian cycle
followed by COH with recombinant follicle-stimulating hormone (FSH). The daily dose
of exogenous gonadotropins for every single patient was modified according to her follicular
growth. The oocytes were retrieved during the oocyte pick up and fertilized by
standard procedures of intracytoplasmic sperm injection (ICSI). The blood samples to
evaluate renal and hepatic functions were taken at the 7th day of ovarian stimulation.
Results: We enrolled 426 women aged between 19 and 44 years, with a mean body mass
index (BMI) of 24.68 Kg/m2. The mean value of blood urea nitrogen was 14 ± 3.16 mg/
dl, creatinine: 1 ± 0.45 mg/dl, uric acid: 4 ± 1.95 mg/dl, total proteins: 7 ± 3.93 mg/dl,
aspartate aminotransferase: 18 ± 6.29 mU/ml, alanine aminotransferase: 19 ± 10.41 mU/
ml, alkaline phosphatase: 81 ± 45.25 mU/ml, total bilirubin 1 ± 0.35 mg/dL. All of the
results were considered as a normal range following the Medical Council of Canada.
Conclusion: Our data suggest that, unlike ovarian hyperstimulation syndrome (OHSS), COH
patients did not show any alteration to renal and hepatic functions.
