Author/Authors :
مقيمي، بهرام نويسنده Department of Genetics, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. , , غريبي، صبا نويسنده Department of Genetics, Faculty of Medicine, International Campus, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. , , فراشاهي يزد، احسان نويسنده Department of Genetics, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran , , طهوري، محمد طاهر نويسنده دانشجوي دکتراي ايمني شناسي، گروه ايمني شناسي، دانشگاه تربيت مدرس تهران، تهران، ايران Tahoori, mohammad taher , كلانتر، سيد مهدي نويسنده استاد گروه ژنتيك، دانشگاه علوم پزشكي و خدمات بهداشتي درماني شهيد صدوقي، يزد، ايران Kalantar, M
Abstract :
MicroRNAs (miRNAs) are small preserved non-coding RNA molecules that regulate gene expression post-transcriptionally by targeting the 3ʹ UTR of mRNAs for translational repression or degradation. The rising evidence has established the significant role of miRNAs within the regulation of immune system and the prevention of autoimmunity. MiR-146a has obtained an importance as a modulator of differentiation and the function of cells of the adaptive, as well as innate immunity rapidly. In this paper, we summarize the recent understanding of the role of miR-146a in adaptive and innate immune responses, as well as in autoimmunity.
