Analysis of TAP1333, TAP1637, TAP2379 Polymorphisms in Patients with Schizophrenia

Background Polymorphism of inflammatory cytokines is an underlying mechanism for the schizophrenia (Scz) development. Objectives The aim of this study is Analysis of TAP1³³³, TAP1⁶³⁷, TAP2³⁷⁹ polymorphisms in patients with Scz. Methods One hundred healthy controls along with 110 cases were assessed in this study. Genotype analyzing of TAP1³³³, TAP1⁶³⁷, TAP2³⁷⁹ polymorphisms was done by Amplification-refractory mutation system (ARMS) PCR. Results Our finding indicated that TAP1-333 polymorphism (OR: 0.1; 95% CI: 0.12-0.813; P: 0.031) and TAP2-379 polymorphism (OR: 2.55; 95% CI: 1.44-4.50; P: 0.001) significantly increased the risk of Scz. However, there was no association between TAP1-637 polymorphism with Scz. Conclusions To the best our knowledge, this study for the first time showed the polymorphisms of TAP1³³³, TAP1⁶³⁷, TAP2³⁷⁹ in the Scz patients. We proposed further investigations with advanced techniques as next generation sequencing for finding new polymorphisms in larger sample sizes in various populations.