Author/Authors :
Ghamarzad Shishavan، Neda نويسنده Faculty of Nutrition, Tabriz University of Medical
Sciences, Tabriz, IR Iran , , Pirouzpanah، Saeed نويسنده Department of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran , , Hajialilo، Mehrzad نويسنده Rheumatology Section, School of Medicine, Tabriz
University of Medical Sciences, Tabriz, IR Iran , , Khabbazi، Alireza نويسنده Connective Tissue Research Center, Tabriz University of Medical Sciences, Tabriz, Iran , , Jafarpour، Farnaz نويسنده Faculty of Nutrition, Tabriz University of Medical
Sciences, Tabriz, IR Iran , , Mirtaheri، Elham نويسنده MSc Student of Nutrition, Student Research Committee, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran , , Farrin، Nazila نويسنده Nutrition Research Center, Faculty of Health and Nutrition, Tabriz University of Medical Science, Tabriz, Iran. , , Ebrahimzadeh، Sima نويسنده Faculty of Nutrition, Tabriz University of Medical
Sciences, Tabriz, IR Iran , , Baban، Navid نويسنده Faculty of Nutrition, Tabriz University of Medical
Sciences, Tabriz, IR Iran , , Shakiba، Zahra نويسنده Faculty of Nutrition, Tabriz University of Medical
Sciences, Tabriz, IR Iran , , Ghahremanzadeh، Kazem نويسنده Danesh Laboratory, Tabriz University of Medical Sciences,
Tabriz, IR Iran ,
Abstract :
Given the high prevalence of rheumatoid arthritis (RA) in females
of reproductive ages, it seems that hormonal factors might be important
in RA pathogenesis. The current study aimed to investigate the
association between females’ reproductive factors occurring prior to the
onset of rheumatoid arthritis and the risk of RA development. This
case-control study was conducted on 231 patients with RA and 238
controls among females aged 26 - 64 years old from the North-West of
Iran. The adjusted risk of RA was assessed using multivariate logistic
regression models. Females ≥ 14 years old at menarche, were more likely
to be at risk of RA (OR = 1.69; 95%CI: 1.08 - 2.64). Advanced maternal
age at first delivery (OR = 1.91; 95%CI: 1.21 - 3.26) and having
abortion (OR = 1.97; 95%CI: 1.23 - 2.99) significantly increased the
risk of RA. Post-menopausal status increased the risk of developing RA
(OR = 2.97; 95%CI: 1.98 - 4.46). Longer duration of breast-feeding was
determined as significant protective variable for RA (P < 0.05).
Subjects with oral contraceptives (OCs) use (OR = 0.36; 95% CI: 0.20 -
0.64), parity (OR = 0.20; 95%CI: 0.06 - 0.70) or large number of
children tended to show rather more reduced risk of RA. The risk of RA
increased with delayed menarche, advanced maternal age at first delivery
and early age at menopause. However, longer duration of breast-feeding,
parity, large number of children and consumption of OCs were found as
protective independent variables against RA.
