Author/Authors :
Hashem Dabaghian، Fataneh نويسنده Research Institute for Islamic and Complementary Medicine, Tehran University of Medical Sciences, Tehran, Iran , , Agah، Shahram نويسنده Colorectal Research Center; Iran University of Medical Sciences, Tehran, Iran , , Taghavi-Shirazi، Maryam نويسنده Research Institute for Islamic and Complementary Medicine,
School of Iranian Traditional Medicine, Iran University of Medical
Sciences, Tehran, IR Iran , , Ghobadi، Ali نويسنده Department of Traditional Pharmacy, Faculty of Traditional Medicine, Tehran University of Medical Sciences, Tehran, IR Iran ,
Abstract :
Gastric Helicobacter pylori is extremely common worldwide. The aim
of this study was to assess the effectiveness of combination of Nigella
sativa and honey (Dosin) in eradication of gastric H. pylori infection.
Nineteen patients who had positive result for H. pylori infection by
urea breath test (UBT) without a past history of peptic ulcer, gastric
cancer or gastrointestinal bleeding, were suggested to receive one
teaspoon of the mixture of Dosin (6 g/day of N. sativa as ground seeds
and 12 g/day of honey) three times a day after meals for two weeks. The
second UBT was used to detect the presence of H. pylori four weeks after
completion of the test. In addition, symptoms of dyspepsia were scored
before and after the study and analyzed with Wilcoxon signed-rank test.
Fourteen patients completed the study. Negative UBT was observed in
57.1% (8/14) of participants after intervention. The median and
interquartile range (IQR) of total dyspepsia symptoms was significantly
reduced from 5.5 (5 - 12) to 1 (0 - 4) (P = 0.005). All the patients
tolerated Dosin except for one who was excluded due to mild diarrhea. No
serious adverse events were reported. Dosin was concluded to be an anti
H. pylori and an anti-dyspeptic agent. Further studies are recommended
to investigate the effect of Dosin plus antibiotics (concurrently or
following another) on gastric H. pylori infection.
