Author/Authors :
Mirghafourvand، Mojgan نويسنده Department of Midwifery, Tabriz University of Medical Sciences, Tabriz , , Homayouni Rad، Aziz نويسنده Department of Food Science and Technology, Faculty of Health and Nutrition, Tabriz University of Medical Sciences , , Mohammad-Alizadeh-Charandabi، Sakineh نويسنده PhD. Assistant Professor, Department of Midwifery, Faculty of Nursing and Midwifery, Tabriz University of Medical Sciences, Tabriz, Iran Mohammad-Alizadeh-Charandabi, Sakineh , Fardiazar، Zahra نويسنده Department of Obstetrics and Gynecology, Tabriz University of Medical Sciences, Tabriz, Iran. , , Shokri، Kolsoum نويسنده Students Research Committee, Faculty of Nursing and
Midwifery, Tabriz University of Medical Sciences, Tabriz, IR
Iran ,
Abstract :
Probiotics can alter the colonic microbiota and might improve bowel
function. The aim of this study was to evaluate the effect of the
consumption of yogurt, enriched with Bifidobacterium and Lactobacillus
4.8 × 1010 (CFU) on the symptoms of constipated pregnant women. This
triple-blind randomized controlled trial was conducted on 60 constipated
pregnant women who were diagnosed by the ROME III criteria in Tabriz,
Iran from December 2014 to July 2015. Participants were randomly put
into two groups including the treatment and the control group through
block randomization. The treatment group received 300 g of yogurt
enriched with Bifidobacterium and Lactobacillus 4.8 × 1010 colony
forming units (CFU) (n = 30) while the control group received
conventional yogurt (n = 30) for 4 weeks. The defecation frequency,
stool consistency, straining during defecation, sensation of anorectal
obstruction, sensation of incomplete evacuation and manual manoeuvres to
facilitate defecation were primary outcomes while the amount of
defecation, stool colure, and quality of life were secondary outcomes.
The frequency of defecation was increased from 2.1 (0.8) at baseline to
8.3 (4.4) in the probiotic yogurt group vs. 2.3 (0.7) at baseline to 8.1
(4.3) in the conventional yogurt group at the end of 4th week. These
results were based on the repeated measure ANOVA test and there was no
statistically significant difference between the two groups (mean
difference: 0.1; Confidence Interval 95%: -1.4 to 1.7; P = 0.872).
Constipation symptoms including straining, anorectal obstruction,
manipulation to facilitate defecation, consistency of stool and color of
stool were improved significantly (P < 0.05) in both groups. In
addition, the amount of defecation was significantly increased in both
groups (P < 0.05), while incomplete evacuation was significantly
reduced in the treatment group (P = 0.01). There was no statistically
significant difference between the groups in the mean scores of physical
(P = 0.726) and mental (P = 0.678) aspects of quality of life after the
intervention with the adjusting of baseline scores. Consumption of 300
g/day probiotic and conventional yogurt can play a role in improving the
symptoms of constipation during pregnancy.
