Author/Authors :
Allami، Abbas نويسنده Assistant Professor, Department of Infectious Disease, Qazvin University of Medical Sci-ence, Qazvin, Iran , , Haji Ali، Farid نويسنده Department of Infectious Diseases, Faculty of Medicine,
Qazvin University of Medical Sciences, Qazvin, Iran , , Jafarpour، Hadise نويسنده Department of Infectious Diseases, Faculty of Medicine,
Qazvin University of Medical Sciences, Qazvin, Iran , , MOHAMMADI، Navid نويسنده Department of Community Medicine, Tehran University of Medical Sciences, Tehran, Iran. ,
Abstract :
A two-step tuberculin skin test (TST) should be performed if the
subsequent TSTs are to be conducted at regular intervals, especially
among health care professionals, and its interpretation of serial TST is
particularly complex. In this randomized controlled clinical trial, the
effect of fish oil fatty acid (FA) supplementation on two-step TST was
investigated. The outcome was considered a change in 2 sequential TST
induration sizes; 6 mm or more were considered as a criterion to
distinguish the increase in reaction size. The study protocol was
approved in the ethic committee of Qazvin University of Medical
Sciences. In the present study, 213 healthy participants (medical and
nursing students of Qazvin University of Medical Sciences in 2014) were
randomly assigned into a normal diet (control) or fish oil
supplementation (treatment) group. One gram of fish oil supplement was
given to the treatment group daily for 5 consecutive days. The mean
secondary induration and the difference between the primary and
secondary induration sizes were significantly higher in the fish oil
users (P < 0.001). Noticeable increase in TST size in the
treatment group was significantly higher than in the control (16.3% vs.
1.2%). Short-term supplementation with fish oil FAs seems to increase
the accuracy of two-step TST.
