Author/Authors :
-، - نويسنده Department of Critical Care Medicine, Taichung Veterans General Hospital, Taichung, 40705, Taiwan Fu, Pin-Kuei , -، - نويسنده School of Traditional Chinese Medicine, Chang Gung University, Taoyuan, Taiwan|Research Center for Industry of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan Pan, Tai-Long , -، - نويسنده Animal Technology Laboratory, Agriculture Technology Research Institute, Miaoli, Taiwan Yang, Chi-Yu , -، - نويسنده Department of Medical Research, Tungs’ Taichung MetroHarbor Hospital, Taichung 43503, Taiwan Jeng, Kee-Ching , -، - نويسنده School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan Tang, Nou-Ying , -، - نويسنده Research Center for Chinese Medicine & Acupuncture, China Medical University, Taichung, Taiwan|Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan|Department of Chinese Medicine, Hsieh, Ching-Liang
Abstract :
Objective(s): Carthamus tinctorius L. (CT) or saffloweris widely used in traditional Chinese medicine. This study investigated the effects of CT extract (CTE) on ischemia–reperfusion (I/R) brain injury and elucidated the underlying mechanism. Materials and Methods: The I/R model was conducted by occlusion of both common carotid arteries and right middle cerebral artery for 90 min followed by 24 hr reperfusion in Sprague-Dawley rats. CTE (0.2-0.6 g/kg) was administered intraperitoneally before and during ischemia, and during reperfusion period. The cerebral infarction area, neurological deficit scores, free radicals (lucigenin chemiluminescence counts) and pro-inflammatory cytokines expression were measured. Results: Pretreatment and treatment with CTE significantly reduced the cerebral infarction area and neurological deficits. CTE (0.4 g/kg) also reduced blood levels of free radicals and expression of tumor necrosis factor-α and interleukin-1β in the cerebral infarction area. Conclusion: The reduction in I/R cerebral infarction caused by CTE is possibly associated with its antioxidation and anti-inflammatory properties.
