Author/Authors :
Mohammadi Ziarani، Ghodsi نويسنده Department of Chemistry, Alzahra University, Tehran, Iran , , Rahimifard، Mahshid نويسنده Department of Chemistry,Alzahra University,Tehran,Iran , , Badiei، Alireza نويسنده School of Chemistry, College of Science,University of Tehran,Tehran,Iran , , Abolhasani Soorki، Ali نويسنده Academic Center for Education, Culture and Research (ACECR), Research Institute of Applied Sciences,Shahid Beheshti University,Tehran,Iran ,
Abstract :
Mesoporous silica LUS-1 (Laval University Silica) was successfully functionalized by propyl sulfonic acid and was used as a recyclable catalyst for the synthesis of acridine-1,8-diones via a pseudo four component reaction of aromatic aldehydes, dimedone and ammonium acetate (or anilines). The excellent yields, short reaction time, simple work-up procedure, and environmentally friendly conditions are advantages of this method. All synthesized compounds were screened for antimicrobial and antifungal activities. Only compound 3e exhibited activity against Bacillus subtilis.
Keywords :
8-dione , Dimedone , Nanoporous acid catalyst , sulfonic acid functionalized LUS-1 , Acridine-1
