Author/Authors :
Torkamandi، Shahram نويسنده Faculty of Medicine,Department of Medical Genetics,Shahid Beheshti University of Medical Sciences,Tehran,Iran , , Bastami، Milad نويسنده Faculty of Medicine,Department of Medical Genetics,Tabriz University of Medical Sciences,Tabriz,Iran , , Ghaedi، Hamid نويسنده Faculty of Medicine,Department of Medical Genetics,Shahid Beheshti University of Medical Sciences,Tehran,Iran , , Moghadam، Fateme نويسنده Imam Hossein Hospital,Shahid Beheshti University of Medical Sciences,Tehran,Iran , , Mirfakhraie، Reza نويسنده Faculty of Medicine,Department of Medical Genetics,Shahid Beheshti University of Medical Sciences,Tehran,Iran , , Omrani، Mir Davood نويسنده Faculty of Medicine,Department of Medical Genetics,Shahid Beheshti University of Medical Sciences,Tehran,Iran ,
Abstract :
Considering that MAPK (mitogen activated protein kinase) signaling pathway has an important role in the progression of inflammatory cytokine secretion in type 2 diabetes mellitus (T2DM), we have recently investigated the reported genetic polymorphism from genome wide association study in MAP3K1 (mitogenactivated protein kinase kinase kinase 1) in diabetes as an important member of MAPK signaling. This study aimed to investigate the possible association of rs10461617 at the upstream of MAP3K1 gene in an Iranian casecontrol study with the risk of T2DM. The study population was comprised of 342 unrelated Iranian individuals including 177 patients with T2DM and 165 unrelated healthy control subjects. Genotyping was performed using PCRRFLP and confirmed with sequencing. In a logistic regression analysis, the rs10461617A allele was associated with a significantly higher risk of T2DM assuming the log additive model (OR: 1.44, 95% CI: 1.012.05, P = 0.039). In conclusion, we provided the first evidence for the association of rs10461617 at the upstream of MAP3K1 with the risk of T2DM in an Iranian population.
Keywords :
type 2 diabetes mellitus , MAP3K1 , genome wide association study , cytokines
