Disorder of Sex Development Part (4)

Normal sex differentiation is the result of long ways and different steps that consecutively take place under the control of relevant enzymes resulting in a normal female or male. Any effective agent and excess or deficit of the relevant enzymes result in the disorder of sex development. The main factors that affect sex development include chromosomal aberration, gonadal dysgenesis, and hormonal effects. Normal sex differentiation and development have been described in the first chapter in the Genetics in the Third Millennium (Vol. 13, No. 1). The disorders of sex development due to chromosomal aberration and gonadal dysgenesis have been delineated in the second (Vol. 13, No. 2) and third chapters (Vol 13, NO. 3). In the fourth chapter, we present and discuss the disorder of sex developments due to hormonal effects.