Author/Authors :
Mohammadianynejad، Seyed Ehsan نويسنده Golestan Hospital, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran , , Kashipazha، Davood نويسنده Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran , , Rezazadeh، Afshin نويسنده Department of Radiology, Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran , , Khademian Ghadikolaii، Mojtaba نويسنده Neurology Department, Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran , , Masoudi Moqaddam، Mehdi نويسنده Neurology Department, Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran , , Tarahomi، Shahram نويسنده Deputy of Health, Social Medicine and Biostatistics, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran , , Sadr، Fatemeh نويسنده Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran , , Nakhostin Mortazavi، Ali نويسنده Neurology Department, Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran , , Naghibi، Seyed Navid نويسنده Golestan Hospital, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran ,
Abstract :
Drooling is an annoying problem in some neurologic and systemic diseases. Injecting botulinum toxin in the salivary glands is one of the most effective and safest treatments. This study was conducted to evaluate the effect of botulinum toxin on the amount of sialorrhea in patients with neurologic diseases. This study included ten patients and 60 units of botulinum toxin type A (Dysport) were injected in any submandibular gland and 120 units were injected in any parotid gland bilaterally under the ultrasonographic guide. To check drooling, daily consumption of tissue was counted and it was cheeked once before injection and at six, 12, 18, and 24 weeks after injection; then the results were compared. In this study, the effect of Dysport on the amount of drooling of the participants at the sixth, 12th, and 18th weeks after treatment was significantly decreased (P value of 0.00016, 0.0001, and 0.00011, respectively). However, after 24 weeks, this difference was not significant (P value = 0.15). These finding showed that Dysport can be significantly effective in reducing the amount of saliva for 18 weeks.
