Is Corneal Sensitivity Sex Dependent?

Purpose: To determine whether corneal sensitivity is different between the two genders. Methods: Corneal sensitivity of 130 normal volunteers, including 77 women and 53 men aged 20‑35 years, with no history of previous ocular surgery was measured using the Cochet‑Bonnet esthesiometer. Measurements were done on five corneal regions: central, nasal, inferior, temporal and superior. The findings were compared between men and women using the non‑parametric Mann‑Whitney U test. Results: Mean age of male subjects was 28.0 years and that of female participants was 26.8 years (P = 0.063). There was a significant difference in corneal sensitivity between men and women in the superior (P = 0.013), temporal (P = 0.020) and inferior (P = 0.046) regions. There was no significant difference in corneal sensitivity in the central (P = 0.862) and nasal (P = 0.273) regions. Conclusion: Except for the central and nasal regions, corneal sensitivity is significantly higher in men as compared to women. The reason for this difference is not yet evident.