Author/Authors :
Samiee Zafarghandi، Anahita نويسنده 1MSc Student in Microbiology, Islamic Azad University, Pharmaceutical Sciences Branch, Tehran, Iran , , Ahmadi Ashtiani، Hamid Reza نويسنده Biochemistry and Nutrition Department of Zanjan Medical University, Zanjan, Iran , , Rezayat، Seyyed Mahdi نويسنده 3Professur of Pharmacology & Toxicology, Department of Pharmacology, School of Medicine, Islamic Azad University, Pharmaceutical Sciences Branch, Tehran, Iran , , Soleimani، Neda نويسنده 4Assistant Professor, Department of Microbiology and Microbial Biotechnology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran , , Hosseinidoost، Seyyed Reza نويسنده Professur of Microbiology, Islamic Azad University, Pharmaceutical Sciences Branch, Tehran, Iran , , Heydarzadeh Khoyi، Shabnam نويسنده 1MSc Student in Microbiology, Islamic Azad University, Pharmaceutical Sciences Branch, Tehran, Iran ,
Abstract :
Background: Silver nanoparticles (Ag-NPs) are the most prominent nanoparticles which are recognized for their high antimicrobial efficacy.
Objectives: The aim of this study was to evaluate the reciprocal pharmaceutical effects and antibacterial activity of Ag-NPs and methanolic extract of Crocus sativus L. (saffron) on some bacterial strains.
Materials and Methods: For evaluation of antibacterial activity of Ag-NPs and methanolic extract of C. sativus L. (saffron) on some bacteria, agar well diffusion method was used. Minimal inhibition concentration (MIC) and minimum bactericidal concentration (MBC) were determined for saffron extract, Ag-NPs, and their combination on methicillin-resistant Staphylococcus aureus (MRSA) and S. pyogenes and S. epidermidis.
Results: The combination of medium concentrations of Ag-NPs (500 ?g/mL) and saffron extract (50 mg/mL) was in the optimum mode to eliminate S. epidermidis and S. pyogenes. The results showed that saffron extract, Ag-NPs, and their combined form had antibacterial effects on these bacteria.
Conclusion: It is suggested to evaluate the synergistic effects of active components of the extract and antimicrobial preservatives used in food, health, pharmaceutical, and cosmetic industries.
