Author/Authors :
Mohammadi Ziarani، Ghodsi نويسنده Department of Chemistry, Alzahra University, Tehran, Iran , , Hosseini Nasab، Narges نويسنده Department of Chemistry,Alzahra University,Tehran,Iran , , Rahimifard، Mahshid نويسنده Department of Chemistry,Alzahra University,Tehran,Iran , , Hajiashrafi، Taraneh نويسنده Department of Chemistry,Alzahra University,Tehran,Iran , , Badiei، Alireza نويسنده School of Chemistry, College of Science,University of Tehran,Tehran,Iran , , Abolhassani Soorki، Ali نويسنده ACECR-Research Institute of Applied Sciences,Shahid Beheshti University,Tehran,Iran ,
Abstract :
A Simple and efficient method for synthesis of tetrahydropyrimido[4,5-b]quinoline derivatives via three component reaction of aromatic aldehydes, dimedone and 6-amino uracil derivatives using a catalytic amount of sulfonic acid functionalized nanoporous silica (SBA-15-Pr-SO3H) is described. The advantages of this method are easy and clean work-up, high yield, mild reaction condition, reusable catalyst and environmentally benign solvents. Antibacterial and antifungal activities of synthesized compounds were measured against gram positive, gram negative bacteriaand fungus. Only compounds 4c and 4g showed activity against Staphylococcus aureus.
Keywords :
4(6)-Amino uracil , Aldehydes , Dimedone , SBA-15-Pr-SO3H , Multi-component reaction
