Author/Authors :
Riaz، Kiran نويسنده , , Misbah Rashid، Muhammad نويسنده , , Mahmood Kayani، Akhtar نويسنده , , Faraz Arshad Malik، Muhammad نويسنده ,
Abstract :
Abstract
Background: Genetic and expression anomaly of HER-2 have been frequently observed in different cancers. However, an overall association
of HER-2 polymorphism (Ile655Val) with available cancer studies has not yet been explored. In the present study, a probable
correlation of HER-2 Ile655Val polymorphism with 6 major types of cancers including breast, lung, gastric, ovarian, thyroid and uterine has
been collectively assessed.
Methodology: Extensive data mining was performed using online available medical research databanks including Pubmed, Ovid, Med-
breast, gastric, lung, ovarian, thyroid and uterine). A database was maintained and updated for case control studies of HER-2 genotype
Ile655Val (rs1136201) information until February 2015. Based on selection criteria, a total of 41 studies containing 37,111 subjects (17845
patients, 19266 controls) were selected for thorough insight about HER-2.
Results:
P
1.20, P
P
PP = 0.0002), Caucasians (co-dominant heterogeneous Ile/Val vs Ile/
PP = 0.01). However, in Asian ethnic group, Ile655Val
Conclusion:
polymorphism in all genetic models.
