Author/Authors :
Ansari، Mansour نويسنده Breast Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran , , Nasrollahi، Hamid نويسنده Dept. of Radiation Oncology, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran , , Rajaei، Majdaddin نويسنده Department of Radiation Oncology, Shiraz University of Medical Sciences, Shiraz, Iran , , Mokhtari، Maral نويسنده Department of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran , , Hamedi، Seyed Hasan نويسنده Dept. of Radiation Oncology, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran , , Mohammadianpanah، Mohammad نويسنده Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran , , Omidvari، Shapour نويسنده Breast Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran , , Mosalaei، Ahmad نويسنده Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences, Shiraz, Iran , , Ahmadloo، Niloofar نويسنده Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran ,
Abstract :
Most bladder tumors are epithelial in origin. Nonepithelial cancers are rarely
located in the bladder. Sarcomas are the most common malignancies among nonepithelial
cancers. Primary bladder lymphoma is rare and mostly low grade. Here, we have reported
a case of diffuse large cell lymphoma of the bladder. The patient, a 64-year-old man,
had urinary frequency for 18 months. Abdominal sonography indicated a thick bladder
wall and transurethral biopsy showed diffuse large cell lymphoma. Immunohistochemistry
(IHC) results showed that the tumor was positive for CD20, CD45, and Pax-5
and negative for BCL-2, cytokeratin, and S100. He had a normal bone marrow biopsy,
abdominal, pelvic and chest CT scans. He had no B symptoms. The patient received
6 cycles of R-CHOP followed by radiotherapy (36 Gy) to the pelvis. Six months after
treatment, the patient is well and has returned to work. We have searched PubMed for
primary diffuse large cell lymphoma. Primary diffuse large cell lymphoma of the
bladder is best treated according to treatment for diffuse large cell lymphoma of other
sites, which includes chemotherapy and radiotherapy. As seen in our review, primary
diffuse large cell lymphoma of the bladder has a similar clinical course to diffuse large
cell lymphoma of other sites.
