Serum leptin in renal transplant patients

Leptin is a small peptide hormone that is mainly produced in adipose tissues. Leptin plays an important role in regulating appetite and energy expenditure and may be involved in modulating bone mineralization. This study was designed to test the association of serum leptin kidney function in renal transplant recipients. We studied 72 kidney transplanted recipients. In this study a significant difference of serum leptin between males and females with higher values in females was seen (p>0.05). There was not relationship between serum leptin with body mass index, age and creatinine clearance (p>0.05). A negative relationship between serum leptin and the duration of kidney transplantation was found (r= -0.26, p= 0.03). The clinical significance of inverse association between serum leptin and the duration of renal transplantation, should consider more in larger studies.