Author/Authors :
Razavi Sayed Mohammad نويسنده Department of Oral and Maxillofacial Pathology, Isfahan University of Medical Sciences, Isfahan, Iran , Homayoni Solmaz نويسنده Department of Oral Pathology, Isfahan University of Medical Sciences, Isfahan, Iran , Khalesi Saeedeh نويسنده Department of Oral and Maxillofacial Pathology, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, IR Iran , Shahnaseri Shirin نويسنده Dental Implant Research Center, Department of Oral and Maxillofacial Surgery, Dental School, Isfahan University of Medical Sciences, Isfahan, Iran Shahnaseri Shirin , Deyhimi Parviz نويسنده Dental Research Center, Dept. of Oral and Maxillofacial Pathology, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran. , Tavakoli Payam نويسنده Dept. of Oral and Maxillofacial Pathology, School of Dentistry, Islamic Azad University of Isfahan (Khorasgan), Isfahan, Iran.
Abstract :
Primary oral melanomas are uncommon malignant neoplasm of melanocytes origin. The most common site of oral melanoma is maxillary gingiva and hard palate. Oral mucosal melanoma exhibit a pathobiological behavior and clinical features different from cutaneous melanomas. Oral melanomas are often clinically silent which may consequently result in delayed diagnosis; thus, making the prognosis extremely poor.
This case report presents clinical, histopathological and immunohistochemical features of two cases of advanced oral melanoma, one pigmented or melanotic melanoma in a 46-year-old female and another amelanotic melanoma in a 59-year-old male patient, with chief complaint of swelling in oral mucosa.
Most oral melanomas are usually asymptomatic lesions with quick growing. Thus, the most cases are detected in late stage of diagnosis. Early diagnosis with careful examination by dentists, and early biopsy of pigmented and suspicious non-pigmented lesions would have an imperative role in more survival rate and better prognosis.
