Author/Authors :
Sahin Fikrettin نويسنده , Somuncu Ozge Sezin نويسنده Department of Genetics and Bioengineering, Faculty of
Engineering and Architecture, Yeditepe University, 26 Agustos
Campus, Kayisdagi cad., Kayisdagi, TR-34755 Istanbul,
Turkey , Kasikci Ezgi نويسنده Department of Genetics and Bioengineering, Faculty of
Engineering and Architecture, Yeditepe University, 26 Agustos
Campus, Kayisdagi cad., Kayisdagi, TR-34755 Istanbul,
Turkey , Somuncu Salih نويسنده Department of Pediatric Surgery, School of Medicine,
Bahçesehir University, Istanbul, Turkey , Tasli Pakize Neslihan نويسنده Department of Genetics and Bioengineering, Faculty of
Engineering and Architecture, Yeditepe University, 26 Agustos
Campus, Kayisdagi cad., Kayisdagi, TR-34755 Istanbul,
Turkey
Abstract :
A previous study performed by the authors of the current study
revealed the characterization and differentiation of newly defined stem
cells known as human newborn foreskin stem cells (hnFSSCs). According to
their stem cell properties, this study aimed at investigating myogenic
differentiation and related tissue engineering. Human newborn foreskin
stem cells were characterized by flow cytometry. The results showed that
hnFSSCs carries a noble prospective for myogenic differentiation and can
be used as a beneficial method for muscle related diseases, including
muscular dystrophy, neuromuscular disorders, muscle damages, muscle
weakness, lesion formations, and other problems associated with tissue
obtainability and multi-potency; these cells may be accepted as
effortlessly accessible and functional, and even superior to other stem
cell origins. Furthermore, hnFFSCs were also seeded onto 3D micro-wells
and Polycaprolactone (PCL) scaffolds in order to examine tissue
development. Human newborn foreskin stem cells on PCL scaffolds showed
good cell-cell integration, so that they may be thought as a stem cell
basis for tissue engineering.
