Author/Authors :
Dobs Adrian S. نويسنده , Lopez David S. نويسنده UTHealth McGovern Medical School- Division of Urology and
UTHealth School of Public Health, Houston, TX , Rohrmann Sabine نويسنده Department of Chronic Disease Epidemiology- University of
Zurich, Zurich, Switzerland , Peskoe Sarah B. نويسنده Department of Epidemiology, Johns Hopkins Bloomberg School
of Public Health, Baltimore, MD , Joshu Corinne E. نويسنده Department of Epidemiology, Johns Hopkins Bloomberg School
of Public Health, Baltimore, MD , Tsilidis Konstantinos K. نويسنده Tsilidis Department of Hygiene and Epidemiology,
University of Ioannina, School of Medicine, Ioannina,
Greece , Selvin Elizabeth نويسنده Department of Epidemiology, Johns Hopkins Bloomberg School
of Public Health, Baltimore, MD , Kanarek Norma نويسنده Department of Oncology, Johns Hopkins University School of
Medicine, Baltimore, MD , Canfield Steven نويسنده UTHealth McGovern Medical School-Division of Urology,
Houston, TX , Nelson William G. نويسنده Department of Urology and the James Buchanan Brady
Urological Institute, Johns Hopkins University School of Medicine,
Baltimore, MD , Platz Elizabeth A. نويسنده Department of Epidemiology, Johns Hopkins Bloomberg School
of Public Health, Baltimore, MD
Abstract :
Background Racial/ethnic disparities in the associations of body
fatness with hormones and metabolic factors remain poorly understood.
Therefore, we evaluated whether the associations of overall and central
body fatness with circulating sex steroid hormones and metabolic factors
differ by race/ethnicity. Methods Data from 1,243 non-Hispanic white
(NHW), non-Hispanic black (NHB) and Mexican-American (MA) adult men in
the third national health and nutrition examination survey (NHANES III)
were analyzed. Waist circumference (central body fatness) was measured
during the physical examination. Percent body fat (overall body fatness)
was calculated from bioelectrical impedance. Associations were estimated
by using weighted linear regression models to adjust the two measures of
body fatness for each other. Results Waist circumference, but not
percent body fat was inversely associated with total testosterone and
SHBG in all three racial/ethnic groups after their mutual adjustment
(all P < 0.0001). Percent body fat (P = 0.02), but not waist
circumference was positively associated with total estradiol in NHB men;
no association was present in NHW and MA men (P-interaction = 0.04).
Waist circumference, but not body fat was strongly positively associated
with fasting insulin (all P < 0.0001) and inversely associated
with HDL cholesterol (all P ≤ 0.003) in all three racial/ethnic groups.
Both percent body fat and waist circumference were positively associated
with leptin (all P < 0.0001) in all three racial/ethnic groups.
Conclusions There was no strong evidence in the associations of sex
hormones and metabolic factors with body fatness in different
racial/ethnic groups. These findings should be further explored in
prospective studies to determine their relevance in racial/ethnic
disparities of chronic diseases.
