Author/Authors :
Figueiredo Anelise Ineu نويسنده Programa de P?s-graduaç?o em Biociências e Reabilitaç?o do
Centro Universit?rio Metodista-IPA, Porto Alegre,
RS-Brazil , Jose Cunha Joao نويسنده Programa de P?s-graduaç?o em Biociências e Reabilitaç?o do
Centro Universit?rio Metodista-IPA, Porto Alegre,
RS-Brazil , Reichert Vital da Silva Ivy نويسنده Programa de P?s-graduaç?o em Biociências e Reabilitaç?o do
Centro Universit?rio Metodista-IPA, Porto Alegre,
RS-Brazil , Luna Martins Laura نويسنده Programa de P?s-graduaç?o em Biociências e Reabilitaç?o do
Centro Universit?rio Metodista-IPA, Porto Alegre,
RS-Brazil , Bard Andreia نويسنده Curso de Fisioterapia do Centro Universit?rio
Metodista-IPA, Porto Alegre, RS-Brazil , Reinaldo Gustavo نويسنده Programa de P?s-graduaç?o em Ciências da Reabilitaç?o,
Universidade Federal de Ciências da Sa?de de Porto Alegre, RS –
Brazil , Rostirola Elsner Viviane نويسنده Programa de P?s-graduaç?o em Biociências e Reabilitaç?o do
Centro Universit?rio Metodista-IPA, Porto Alegre,
RS-Brazil , Padilha de Souza Maristela نويسنده Programa de P?s-graduaç?o em Biociências e Reabilitaç?o do
Centro Universit?rio Metodista-IPA, Porto Alegre,
RS-Brazil
Abstract :
Background Emerging evidence point out that exercise is an
epigenetic modulator and is able to alter brain-derived neurotrophic
factor (BDNF) levels in different populations. However, little is known
about the impact of exercise on these markers in well-trained aged
individuals, making this research topic particularly relevant.
Objectives Therefore, the current study aimed at investigating the
impact of the regular running practice on global histone H4 acetylation
and brain–derived neurotrophic factor (BDNF) levels as well as on the
functional mobility in healthy elderly males. Methods Fifteen male
volunteers aged 60 years and older were recruited. They were allocated
into 2 groups: runners (RUN, n = 8) and sedentary (SED, n = 7), taking
into account the question that they were sedentary or amateur street
runners. Whole blood samples (15 mL) were collected for the biochemical
measurements and the functional mobility assessment was performed
through the timed up and go (TUG) test. The biochemical analyses were
determined using specific kits, according to the manufacturer’s
instructions. Results The RUN group showed a significant increase in
plasma BDNF levels (P = 0.007) and H4 hypoacetylation status (P <
0.001) in peripheral mononuclear cells (PBMCs), compared with the SED
individuals. The RUN group also presented significantly lower values in
TUG, an indicative of better motor performance (P = 0.02). Conclusions
Collectively, the current study data suggested that the modulation of
histone H4 acetylation status might emerge as an important biomarker
related to the elderly runners phenotype. The data also supported the
idea that the running practice enhances peripheral BDNF levels, which
could be linked to the functional mobility improvement in the elderly
runners.
