Author/Authors :
Ghaderi Abbas نويسنده , Samsami Dehaghani Alamtaj نويسنده Department of Obstetrics and Gynecology, Shiraz University of Medical Sciences, Shiraz, Iran , Abtahi Shabnam نويسنده Department of Pediatric Surgery, Pediatric Medical Center, Tehran University of Medical Sciences, Tehran, Iran , Faraji Aazam نويسنده Department of Obstetrics and Gynecology, School of
Medicine, Shiraz, Iran
Abstract :
Background Postmenopausal osteoporosis is a major cause of
morbidity in postmenopausal females. Transforming growth factor β1
(TGF-β1) and interleukin 18 (IL-18) play complex roles in normal bone
metabolism, and in pathophysiology of postmenopausal osteoporosis.
Objectives The aim of this study was to design an analytic cross
sectional study in order to further clarify the role of TGF-β1 and IL-18
in osteoporosis of postmenopausal females. Methods A cross sectional
study including 65 postmenopausal osteoporotic females as cases and 69
postmenopausal females of similar age without osteoporosis as controls
was conducted. Dual energy X-ray absorptiometry (DXA) was used to
determine bone mass density (BMD) of participants and T-scoring was
applied to establish whether the patient has osteoporosis or not. Serum
TGF-β1 and IL-18 levels were measured by quantitative sandwich Enzyme
linked immunosorbent assay (ELISA). Results Serum TGF-β1 levels were
significantly higher in osteoporotic postmenopausal females than
non-osteoporotic individuals (23.8 vs. 15.8 ng/mL; P = 0.009). There was
no difference between IL-18 levels in the sera of osteoporotic and
non-osteoporotic postmenopausal females in this study. There was a
positive correlation between body mass index (BMI) and serum level of
TGF-β1 (P = 0.04). Conclusions Our study demonstrated that TGF-β1 serum
levels is higher in osteoporotic postmenopausal females than
non-osteoporotic ones, and probably aberrant increase in TGF-β1 in
postmenopausal females can result in uncoupled bone resorption and
formation, which leads to osteoporosis.
